热烈祝贺顶级期刊Nature genetics于2016年12月5日正式在线发表了我公司客户所属的中国水产科学研究院黄海水产研究所陈松林团队的以《The genome and transcriptome of Japanese flounder provide insights into flatfish asymmetry》为名的论文！谱领生物为其提供了关键性化合物（代谢物）的精确定量检测分析服务。
本篇论文，从基因组、转录组以及与代谢之间的关联等方面系统性研究分析了Japanese flounder和flatfish asymmetry两种比目鱼的差异。
Title:The genome and transcriptome of Japanese flounder provide insights into flatfish asymmetry；
Author：Changwei Shao1,2,14, Baolong Bao3,14, Zhiyuan Xie4,14, Xinye Chen3,14, Bo Li4,14, Xiaodong Jia1,2,14, Qiulin Yao4, Guillermo Ortí5, Wenhui Li4, Xihong Li1,2, Kristin Hamre6,7, Juan Xu3, Lei Wang1,2, Fangyuan Chen4, Yongsheng Tian1,2, Alex M Schreiber8, Na Wang1,2, Fen Wei3, Jilin Zhang4, Zhongdian Dong1,2, Lei Gao3, Junwei Gai3, Takashi Sakamoto9, Sudong Mo1,2, Wenjun Chen3, Qiong Shi4, Hui Li3, Yunji Xiu1,2, Yangzhen Li1,2, Wenteng Xu1,2, Zhiyi Shi3, Guojie Zhang4, Deborah M Power10,11,15, Qingyin Wang1,2,15, Manfred Schartl12,13,15 & Songlin Chen1,2,15；
Journal:Nature genetics（IF=27.96）;published online 5 December 2016; doi:10.1038/ng.3732；
Flatfish have the most extreme asymmetric body morphology of vertebrates. During metamorphosis, one eye migrates to the contralateral side of the skull, and this migration is accompanied by extensive craniofacial transformations and simultaneous development of lopsided body pigmentation1–5. The evolution of this developmental and physiological innovation remains enigmatic. Comparative genomics of two flatfish and transcriptomic analyses during metamorphosis point to a role for thyroid hormone and retinoic acid signaling, as well as phototransduction pathways. We demonstrate that retinoic acid is critical in establishing asymmetric pigmentation and, via cross-talk with thyroid hormones, in modulating eye migration. The unexpected expression of the visual opsins from the phototransduction pathway in the skin translates illumination differences and generates retinoic acid gradients that underlie the generation of asymmetry. Identifying the genetic underpinning of this unique developmental process answers long-standing questions about the evolutionary origin of asymmetry, but it also provides insight into the mechanisms that control body shape in vertebrates.