客户论文
2020：
吉林大学动物医学学院-乳腺炎-肠道菌群-短链脂肪酸定量
HU Xiaoyu, GUO Jian, ZHAO Caijun, JIANG Peng, MAIMAI T, YANYI Li, CAO Yongguo, FU Yunhe*, ZHANG Naisheng*. The gut microbiota contributes to the development of Staphylococcus aureus-induced mastitis in mice. ISME Journal. 2020,14(7):1897-1910. Full text （影响因子 9.180，JCR 一区）
甘肃农业大学动物医学院-小鼠-胆汁酸绝对定量
JIA Yaqian, YUAN Ziwen, ZHANG Xiaosong, DONG Jiaqi, LIU Xuenan, PENG Xiaoting, YAO Wanling, JI Peng, WEI Yanming, HUA Yongli*. Total alkaloids of Sophora alopecuroides L. ameliorated murine colitis by regulating bile acid metabolism and gut microbiota. Journal of Ethnopharmacology. 2020, 255: 112775. Full text（影响因子 3.690，JCR 二区）
中国农业大学食品科学与营养工程学院-高脂饮食小鼠肠道菌群与白藜芦醇-代谢组与定量
WANG Pan, GAO jianpeng, KE Weixin, WANG Jing, LI Daotong, LIU Ruolin, JIA Yan, WANG Xuehua, CHEN Xin, CHEN Fang, HU Xiaosong*. Resveratrol reduces obesity in high-fat diet-fed mice via modulating the composition and metabolic function of the gut microbiota. Free Radic Biol Med. 2020,156: 83-98. Full text（影响因子 6.170，JCR 一区）
中国医学科学院基础医学研究所-神经(胶质母细胞瘤)-代谢流
FU Yi, WANG Dongdong, HE Wei*, ZHANG Jianmin*, et al. TSPO deficiency induces mitochondrial dysfunction, leading to hypoxia, angiogenesis, and a growth-promoting metabolic shift toward glycolysis in glioblastoma. Neuro-oncology, 2020, 22(2): 240-252. Full text（影响因子 10.247，JCR 一区）
上海交通大学医学院附属瑞金医院-高血压-细胞-代谢流
GAO Jing, WEI Tong, HUANG Chenglin, SUN Mengwei, SHEN Weili*. Sirtuin 3 governs autophagy‐dependent glycolysis during Angiotensin II‐induced endothelial‐to‐mesenchymal transition. FASEB Journal, 2020, 34(12): 16645-16661. Full text （影响因子 4.966，JCR 一区）
上海交通大学医学院附属瑞金医院-2型糖尿病-肠道菌群-胆汁酸定量
QIU Yixuan, SHEN Linyan, NING Guang* (中国工程院院士), GU Yanyun*, et al. The glucose-lowering effects of α-glucosidase inhibitor require a bile acid signal in mice. Diabetologia. 2020, 63(5): 1002-1016. Full text （影响因子 7.518，JCR 一区）
上海交通大学医学院附属瑞金医院-鼠失血性休克-肝损伤-胆汁酸定量
SUN Silei, ZHAO Bing, CHEN Erzhen*, MAO Enqiao*. TUDCA ameliorates liver injury via activation of SIRT1-FXR signaling in a rat hemorrhagic shock model. Shock. 2020, 53(2): 217-222. Full text （影响因子 2.960，JCR 二区）
上海交通大学医学院附属第九人民医院-眼病-临床血清-脂质组学
FANG Sijie, ZHANG Shuo, HUANG Yazhuo, ZHOU Huifang*, FAN Xianqun*, et al. Evidence for associations between Th1/Th17 "Hybrid" phenotype and altered lipometabolism in very severe graves orbitopathy. Journal of Clinical endocrinology & Metabolism. 2020, 105(6): dgaa124. Full text （影响因子 5.493，JCR 一区）
广东省科学院广东省微生物研究所-粪便-代谢组学
CHEN Diling, GUO Yinrui, XIE Yizhen*, WU Qingping*, et al. Metabolic regulation of Ganoderma lucidum extracts in high sugar and fat diet-induced obese mice by regulating the gut-brain axis. Journal of Functional Foods. 2020, 65: 103639. Full text （影响因子 3.701，JCR 二区）
浙江大学医学院-心肌细胞铁死亡-靶向代谢物定量（谷胱甘肽、半胱氨酸等）
FANG Xuexian, CAI Zhaoxian, MIN Junxia*, WANG Fudi*, et al. Loss of cardiac ferritin H facilitates cardiomyopathy via Slc7a11-mediated ferroptosis. Circulation Research. 2020, 127(4): 486-501. Full text （影响因子 14.467，JCR 一区）
中国农业大学-肾衰竭-尿毒症毒素-肠道微生物(肠道菌群)-粪便代谢物定量（胆汁酸）
WANG Xifan, YANG Songtao, Ehrlich Stanislav Dusko*, REN Fazheng*, YU Zhengquan*, et al. Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents. Gut. 2020, 69(12): 2131-2142. Full text （影响因子 19.819，JCR 一区）
华中农业大学动物医学院-寄生虫(弓形虫)-脂肪酸代谢流
LIANG Xiaohan, CUI Jianmin, SHEN Bang*, et al. Acquisition of exogenous fatty acids renders apicoplast-based biosynthesis dispensable in tachyzoites of Toxoplasma. Journal of Biological Chemistry. 2020, 295(22): 7743-7752. Full text （影响因子 4.238）
中国农业科学院深圳农业基因组研究所-植物（拟南芥）-植物激素定量
LIU Fei, ZHANG Hui, DING Ling, XIANG Yong*, et al. REVERSAL OF RDO5 1, a Homolog of rice seed dormancy 4, interacts with bHLH57 and controls ABA biosynthesis and seed dormancy in Arabidopsis. Plant Cell, 2020, 32(6): 1933-1948. Full text （影响因子 8.631，JCR 一区）
华中农业大学水产学院-TDCIPP环境污染-毒性-斑马鱼-神经递质定量
DING Xisheng, SUN Wen, DAI Lili, LIU Chunsheng, SUN Qian, WANG Jianghua, ZHANG Panwei, LI Kun, YU Liqin*.Parental exposure to environmental concentrations of tris(1,3-dichloro-2-propyl)phosphate induces abnormal DNA methylation and behavioral changes in F1 zebrafish larvae. Environmental Pollution, 2020, 267: 115305. Full text （影响因子 6.791，JCR 一区）
上海中医药大学附属龙华医院-中药药理-代谢组
ZHU Mingzhe, LI Meng, ZHANG Li*, JI Gaung*, et al. Metabolomic analysis identifies glycometabolism pathways as potential targets of Qianggan Extract in hyperglycemia rats. Frontiers in Pharmacology, 2020, 11: 671. Full text （影响因子 4.225，JCR 一区）
复旦大学附属中山医院-免疫（巨噬细胞）-代谢流
DONG Zhen, LI Ruoshui, XU Lei, XIN Kaiyue, SUN Aijun*, GE Junbo* (中国工程院院士), et al. Histone hyperacetylation mediates enhanced IL-1β production in LPS/IFN-γ-stimulated macrophages. Immunology, 2020, 160(2): 183-197. Full text （影响因子 5.016，JCR 二区）
中国农业大学草业科学与技术学院-植物（苜蓿）-代谢组学
CHEN Lingling, XIA Fangsha, MAO Peisheng*, et al. Metabolomic analyses of alfalfa (Medicago sativa L. cv. ‘Aohan’) reproductive organs under boron deficiency and surplus conditions. Ecotoxicology and Environmental Safety, 2020, 202: 111011. Full text （影响因子 4.872，JCR 一区）
2019：
中国医学科学院北京协和医学院-病毒与细胞-代谢组&代谢物定量
LIU Yang, YOU Yuling, CAO Xuetao* (中国工程院院士), et al. N6-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication. Science, 2019, 365: 1171-1176. Full text （影响因子 41.845，JCR 一区）
复旦大学附属华山医院-肝癌细胞-乙酰辅酶A定量
LU Ming*, ZHU Wen-Wei, QIN Lun-Xiu*, et al. ACOT12-dependent alteration of acetyl-CoA drives hepatocellular carcinoma metastasis by epigenetic induction of epithelial-mesenchymal transition. Cell Metabolism, 2019, 29: 886-900. Full text （影响因子 21.567，JCR 一区）
河南大学基础医学院-纳米材料毒性-动物血清-代谢组学
YANG Yanjie, LV Shuangyu*, JI Shaoping*, et al. Toxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice. International Journal of Nanomedicine, 2019, 14: 6297-6311. Full text （影响因子 5.115，JCR 二区）
中国科学院上海生物化学与细胞生物学研究所-神经-恶性胶质瘤细胞-糖代谢定量
WANG Xiongjun, LIU Ruilong, LI Guohui*, YANG Weiwei*, et al. α-Ketoglutarate-activated NF-κB signaling promotes compensatory glucose uptake and brain tumor development. Molecular Cell, 2019, 76(1): 148-162.e7 Full text （影响因子 15.584，JCR 一区）
中国农业大学食品科学与营养工程学院-肥胖与代谢综合征-中药生姜-糖代谢定量
WANG Jing, LI Daotong, WANG Pan, HU Xiaosong, CHEN Fang. Ginger prevents obesity through regulation of energy metabolism and activation of browning in high-fat diet-induced obese mice. Journal of Nutritional Biochemistry. 2019, 70: 105-115. Full text （影响因子 4.873，JCR 一区）
昆明理工大学-灵长类动物(食蟹猴)-血与脑脊液-神经递质定量
ZHANG Bo*, ZHOU Zhigang, JI Weizhi (中国科学院院士), CHEN Yongchang*, et al. Social‐valence‐related increased attention in rett syndrome cynomolgus monkeys: An eye‐tracking study. Autism Research, 2019, 12: 1585–1597. Full text （影响因子 3.727，JCR 三区）
上海交通大学医学院-肥胖相关的胰岛素抵抗-支链氨基酸与支链羰酸定量
ZHOU Meiyi, SHAO Jing, WU Cheng-Yang, SHU Le, SUN Haipeng*, et al. Targeting BCAA catabolism to treat obesity-associated insulin resistance. Diabetes. 2019, 68(9): 1730-1746. Full text （影响因子 7.72，JCR 一区）
上海中医药大学附属龙华医院-中药-动物糖尿病-血清组织粪便-代谢组学
LI Meng, DANG Yanqi, ZHANG Li*, JI Guang*, et al. Berberine alleviates hyperglycemia by targeting hepatic glucokinase in diabetic db/db mice. Scientific Reports. 2019, 9(1): 8003. Full text （影响因子 3.998，JCR 一区）
上海东方肝胆医院-临床-肝癌组织-代谢物定量
LIU Jiao, JIANG Jinhua, WANG Hailin*, HE Yufei*, WANG Hongyang*, et al. Global DNA 5-hydroxymethylcytosine and 5-formylcytosine contents are decreased in the early stage of hepatocellular carcinoma. Hepatology, 2019, 9(1): 196-208. Full text （影响因子 14.679，JCR 一区）
上海中医药大学-肠道菌群-血清-GC-MS非靶向代谢组学
GU Yu, LIU Can, ZHANG Weidong*, LI Houkai*, et al. Metabolic and gut microbial characterization of obesity-prone mice under a high-fat diet. Journal of Proteome Research, 2019, 18(4): 1703-1714. Full text （影响因子 4.074，JCR 一区）
中国科学院上海生物化学与细胞生物学研究所-肿瘤细胞-代谢流
LIU Ruilong, LI Wenfeng, YANG Weiwei*, et al. Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance. Nature Communications, 2019, 10: 991. Full text （影响因子 12.121，JCR 一区）
华中农业大学-寄生虫机制-代谢流 美国微生物协会期刊
XIA Ningbo, YE Shu, LIANG Xiaohan, SHEN Bang*, et al. Pyruvate homeostasis as a determinant of parasite growth and metabolic plasticity in Toxoplasma gondii. mBio, 2019, 10: e00898-19. Full text （影响因子 6.784，JCR 一区）
中国农业大学-药物毒理学-动物组织-脂质组
YANG Xuan, XU Wentao, HE Xiaoyun*, et al. Precision toxicology shows that troxerutin alleviates ochratoxin A–induced renal lipotoxicity. FASEB Journal, 2019, 33(2): 2212-2227. Full text （影响因子 4.966，JCR 一区）
中国医学科学院病原生物学研究所-病毒(寨卡病毒)-细胞和组织-脂质组学
ZHOU Jia, CHI Xiaojing, YANG Wei*, et al. Zika virus degrades the ω-3 fatty acid transporter Mfsd2a in brain microvascular endothelial cells and impairs lipid homeostasis. Science Advances. 2019, 5(10): eaax7142. Full text （影响因子 13.116，JCR 一区）
2018：
北京生命科学研究所北京蛋白质组研究中心-肝癌-细胞-代谢组与脂质组学
CAI Mengjiao, SUN Xiao, HAN Suxia*, CHEN Huan*, ZHANG Pumin*, et al. Disruption of peroxisome function leads to metabolic stress, mTOR inhibition, and lethality in liver cancer cells. Cancer Letters, 2018, 421: 82-93. Full text （影响因子 7.360，JCR 一区）
中南大学湘雅医院-肺癌-细胞-代谢流
LI Jiangjiang, HE Ya, CAO Ya*, et al. Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancer. Theranostics, 2018, 8(15): 4050-4061. Full text （影响因子 8.579，JCR 一区）
复旦大学附属上海公共卫生临床中心-艾滋病-血浆-色氨酸代谢物定量
CHEN Jun, XUN Jingna, LU Hongzhou*, et al. Plasma indoleamine 2, 3-dioxygenase activity is associated with the size of the human immunodeficiency virus reservoir in patients receiving antiretroviral therapy. Clinical Infectious Diseases, 2018, 68(8): 1274-1281. Full text （影响因子 8.313，JCR 一区）
上海交通大学医学院附属瑞金医院-2型糖尿病-抗生素-血浆-粪便-肠道菌群-短链脂肪酸-胆汁酸定量
FU Lihong, QIU Yixuan, NING Guang (中国工程院院士), NIE Aifang*, GU Yanyun*, et al. The delayed effects of antibiotics in type 2 diabetes, friend or foe? Journal of Endocrinology, 2018, 238(2): 137-149. Full text （影响因子 4.041，JCR 一区）
暨南大学生物转化医学研究院-高云飞团队-代谢流
XIA Xichun, ZHOU Wei, GUO Chengbin, FU Zhen, ZHU Leqing, LI Peng, XU Yan, ZHENG Liangyan, ZHANG Hua, SHAN Changliang, GAO Yunfei*. Glutaminolysis Mediated by MALT1 Protease Activity Facilitates PD-L1 Expression on ABC-DLBCL Cells and Contributes to Their Immune Evasion. Front Oncol. 2018, 8: 632. Full text （影响因子 4.848，JCR 二区）
中国科学院上海生物化学与细胞生物学研究所-杨巍维团队-巨噬细胞-代谢流
ZHANG Yajuan, YU Guanzhen, LI Guohui*, YANG Weiwei*, et al. Macrophage-associated PGK1 phosphorylation promotes aerobic glycolysis and tumorigenesis. Molecular Cell, 2018, 71(2): 201-215.e7 Full text （影响因子 15.584，JCR 一区）
四川农业大学-植物组织(玉米幼苗)-缺磷-基因组-非靶向代谢组学
LUO Bowen, MA Peng, GAO Shibin*, et al. Metabolite profiling and genome-wide association studies reveal response mechanisms of phosphorus deficiency in maize seedling. Plant Journal, 2018, 97(5): 947–969. Full text （影响因子 6.141，JCR 一区）
西北农林科技大学-动物(鸡)-非酒精性脂肪肝-脂代谢-叶酸-非靶向代谢组
LIU Yanli, SHEN Jing, YANG Xiaojun*, et al. Folic acid reduced triglycerides deposition in primary chicken hepatocytes. Journal of Agricultural and Food Chemistry, 2018, 66: 13162-13172. Full text （影响因子 4.192，JCR 一区）
中国农科院植物保护研究所-贝莱斯芽孢杆菌-非靶向代谢组
WANG Junqiang, GUO Rongjun*, LI Shidong*, et al. Insight into the surfactin production of Bacillus velezensis B006 through metabolomics analysis. Journal of Industrial Microbiology & Biotechnology, 2018, 45(12):1033-1044. Full text （影响因子 1.681，JCR 二区）
上海交通大学医学院附属仁济医院-结肠癌-细胞-代谢组学&代谢流
WANG Yun-Qian, WANG Hao-Lian, CHEN Ying-Xuan*, et al. Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner. Nature Communications. 2018, 9: 545. Full text （影响因子 12.121，JCR 一区）
中国农业大学-肠道微生物(肠道菌群)-粪便-短链脂肪酸-芳香类物质-非靶向代谢组&靶向定量(芳香类物质定量)
LI Daotong, WANG Pan, CHEN Fang*, et al. Gut microbiota promotes production of aromatic metabolites through degradation of barley leaf fiber. Journal of Nutritional Biochemistry, 2018, 58: 49-58. Full text （影响因子 4.873，JCR 一区）
华中农业大学水产学院-环境污染-神经毒性-斑马鱼-神经递质定量
GUO Xiaochun, ZHANG Shengnan, LU Shaoyong*, ZHENG Binghui, XIE Ping, CHEN Jun, LI Guangyu, LIU Chunsheng, WU Qin, CHENGE Houcheng, SANG Nan. Perfluorododecanoic acid exposure induced developmental neurotoxicity in zebrafish embryos. Environmental Pollution, 2018, 241: 1018-1026. Full text （影响因子 6.791，JCR 一区）
华中农业大学-寄生虫-细胞-代谢流
XIA Ningbo, YANG Jichao, SHEN Bang*, et al. Functional analysis of Toxoplasma lactate dehydrogenases suggests critical roles of lactate fermentation for parasite growth in vivo. Cellular Microbiology, 2018, 20(1): e12794. Full text （影响因子 3.430，JCR 二区）
西北农林科技大学动物科技学院-鸡-肝脏-非靶向代谢组学
WU Shengru, LIU Yanli, YANG Xiaojun*, et al. Hepatic metabolomic profiling changes along with postnatal liver maturation in breeder roosters. Biology Open, 2018, 7(1): bio028944. Full text （影响因子 2.029，JCR 三区）
2017：
华南农业大学-病毒-细胞-非靶向代谢组学 Front. Microbiol. IF=4.235
GOU Hongchao, ZHAO Mingqiu, CHEN Jinding*, et al. Metabolic profiles in cell lines infected with classical swine fever virus. Frontiers in Microbiology, 2017, 8: 691. Full text
上海海洋大学-鱼组织-靶向代谢物(视黄酸)定量 Nat. Genet. IF= 27.603
SAHO Changwei, BAO Baolong, Xie ZY, POWER Deborah M*, WANG Qingyin*, SCHARTL Manfred*, CHEN Songlin*, et al. The genome and transcriptome of Japanese flounder provide insights into flatfish asymmetry. Nature Genetics, 2017, 49: 119-124. Full text
上海交通大学医学院附属瑞金医院-临床2型糖尿病-肠道菌群-血浆胆汁酸定量 Nature Communications IF=12.121
GU Yanyun, WANG Xiaokai, Kristiansen Karsten*, NING Guang*, WANG Weiqing*, et al. Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment. Nature Communications, 2017, 8: 1785. Full text
上海交通大学医学院附属瑞金医院-肥胖-肠道菌群-血清-非靶向代谢组-靶向代谢物定量 Nature Medicine IF=36.130
LIU Ruixin, HONG Jie, NING Guang* (中国工程院院士), Kristiansen Karsten*, WANG Weiqing*, et al. Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention. Nature Medicine, 2017, 23: 859-868. Full text
上海交通大学医学院附属瑞金医院-肥胖-细胞-靶向代谢物定量 Endocrine IF=3.235
NING Tinglu, ZOU Yaoyu, WANG Jiqiu*, NING Guang* (中国工程院院士), et al. Genetic interaction of DGAT2 and FAAH in the development of human obesity. Endocrine, 2017, 56(2): 366-378. Full text
上海中医药大学-肠道菌群-血清-非靶向代谢组-靶向定量（胆汁酸）Journal of proteome research IF=4.074
HE Xuyun, ZHENG Ningning, HE Jiaojiao, LIU Can, FENG Jing, JIA Wei*, LI Houkai*. Gut microbiota modulation attenuated the hypolipidemic effect of simvastatin in high-fat/cholesterol-diet fed mice. J Proteome Res. 2017,16(5): 1900-1910. Full text
上海中医药大学-中药毒性研究-尿液-非靶向代谢组学
HU Xueqing, SHEN Jiaying, PU Xueyan, ZHENG Ningning, DENG Zhongping, ZHANG Zean, LI Houkai*. Urinary time- or dose-dependent metabolic biomarkers of aristolochic acid-induced nephrotoxicity in rats. Toxicological Sciences. 2017, 156(1): 123-132. Full text （影响因子 3.703，JCR 一区）
华中农业大学水产学院-微囊藻毒素-神经毒性-斑马鱼-神经递质定量
WU Qin, YAN Wei, CHEN Houcheng, LIU Chunsheng, HUNG Tien-Chieh, GUO Xiaochun, LI Guangyu*. Parental transfer of microcystin-LR induced transgenerational effects of developmental neurotoxicity in zebrafish offspring. Environmental Pollution, 2017, 231: 471-478. Full text （影响因子 6.971，JCR 一区）
中国科学院-食管癌-靶向定量-色氨酸代谢 Biochem Biophys Res Commun. IF=2.985
CHENG Jing, JIN Hai, ZHENG Guangyong*, GAO Xianfu*. Disturbed tryptophan metabolism correlating to progression and metastasis of esophageal squamous cell carcinoma. Biochem Biophys Res Commun. 2017, 486(3): 781-787. Full text
2016：
江南大学-菌微生物大肠杆-Plos One-GC-MS非靶向 IF 3.234
Liu LN, Duan XG, Wu J. L-Tryptophan Production in Escherichia coli Improved by Weakening the Pta-AckA Pathway. Plos One, 2016.
江南大学-菌微生物大肠杆-Journal of Biotechnology-GC-MS非靶向 IF 3.163
Liu LN, Duan XG, Wu J.Modulating the direction of carbon flow in Escherichia coli to improvel-tryptophan production by inactivating the global regulator FruR. Journal of Biotechnology, 2016.
上海中医药大学-高血脂症药物治疗研究-大鼠血清肝脏粪便-Journal of Tranlational Medicine-GC-MS非靶向 IF 4.098
Li M, Shu XB, Ji G, et al. Integrative analysis of metabolome and gut microbiota in dietinduced hyperlipidemic rats treated with berberine compounds. Journal of Tranlational Medicine, 2016.
扬州大学-肠道菌群-血浆-Scientific Reports GC-MS靶向（短链脂肪酸） IF 4.011
Liu L, Zhao X, Gong DQ, et al. Prosteatotic and Protective Components in a Unique Model of Fatty Liver: Gut Microbiota and Suppressed Complement System. Scientific Reports, 2016.
