客户论文
2025年：
Wang N, Lu S, Cao Z, Li H, Xu J, Zhou Q, Yin H, Qian Q, Zhang X, Tao M, Jiang Q, Zhou P, Zheng L, Han L, Li H, Yin L, Gu Y, Dou X, Sun H, Wang W, Piao HL, Li F, Xu Y, Yang W, Chen S, Liu J. Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism. Cell Metab. 2025 Jun 3; 37(6): 1381-1399.e9. Full text（影响因子27.7，中科院1区/JCR Q1区，BCAA支链氨基酸代谢 酰基辅酶A和TCA循环-定量和代谢流）
Cheng ZL, Zhang S, Wang Z, Song A, Gao C, Song JB, Wang P, Zhang L, Zhou Y, Shan W, Zhang C, Zhang J, Sun Y, Xu Y, Lan F, Zhong M, Lyu LD, Huang G, Chen FX, Li G, Wang Z, Chen F, Xue J, Shi J, Liu Y, Lin Z, Wu D, Na J, Chen LL, Guan KL, Xiong Y, Ye D. Pathogen-derived glyoxylate inhibits Tet2 DNA dioxygenase to facilitate bacterial persister formation. Cell Metab. 2025 May 6; 37(5):1137-1151.e5. Full text（影响因子27.7，中科院1区/JCR Q1区，乙醛酸定量）
Gan G, Zhou X, Zheng Q, Gao X, Chen X, Zhang H, Liu J, Shi Z, Chen F. 3-Hydroxyanthranic acid inhibits growth of oral squamous carcinoma cells through growth arrest and DNA damage inducible alpha. Transl Oncol. 2025 Feb; 52: 102278. Full text（影响因子4.5，中科院3区/JCR Q2区，色氨酸代谢物定量）
Zhang C, Qiao P, Xiao C, Cao Z, Chen J, Fang H, Yang J, Kang Z, Dang E, Shao S, Pang B, Li Q, Zhu Z, Shen S, Hasegawa A, Abe R, Qiao H, Wang G, Fu M. Exosomal miR-375-3p mediated lipid metabolism, ferritinophagy and CoQ-dependent pathway contributes to the ferroptosis of keratinocyte in SJS/TEN. Int J Biol Sci. 2025 Jan 20;21(3):1275-1293. Full text（影响因子8.1，中科院2区/JCR Q1区，脂质组学-氧化脂肪酸Oxylipins）
2024年：
Shen J, Xie E, Shen S, Song Z, Li X, Wang F, Min J. Essentiality of SLC7A11-mediated nonessential amino acids in MASLD. Science Bulletin. 2024, Dec 15; 69(23): 3700-3716. Full text （影响因子18.8，中科院1区/JCR Q1区，铁死亡-代谢组-代谢流-氨基酸定量）
Maremonti E, Brede DA, Kassaye YA, Zheng K, Lee Y, Salbu B, Teien HC. Dose rate dependent genotoxic and metabolic effects predict onset of impaired development and mortality in Atlantic salmon (S. salar) embryos exposed to chronic gamma radiation. Sci Total Environ. 2024 Dec 1; 954:176263. Full text （影响因子8.2，中科院1区/JCR Q1区，环境科学-三文鱼-GC-MS非靶代谢组学）
Ovlyakulov B, Hu B-L, Kan H-Y, Guo Q, Li X-F, Fan H-H, Wu H-W, Wang J-Y, Zhang X , Zhu J-H. Escitalopram moderately outperforms citalopram towards anti-neuroinflammation and neuroprotection in 6-hydroxydopamine-induced mouse model of Parkinson's disease, Int Immunopharmacol. 2024, Sep 30; 139: 112715, Full text （影响因子4.8，中科院2区/JCR Q1区，神经递质定量）
Shao T, Gao Q, Ma Y, Gu J, Yu Z. Hyperforin improves matrix stiffness induced nucleus pulposus inflammatory degeneration by activating mitochondrial fission. Int Immunopharmacol. 2024, Aug 20; 137: 112444. Full text （影响因子4.8，中科院2区/JCR Q1区，靶向糖代谢组定量）
Wu C, Yang F, Zhong H, Hong J, Lin H, Zong M, Ren H, Zhao S, Chen Y, Shi Z, Wang X, Shen J, Wang Q, Ni M, Chen B, Cai Z, Zhang M, Cao Z, Wu K, Gao A, Li J, Liu C, Xiao M, Li Y, Shi J, Zhang Y, Xu X, Gu W, Bi Y, Ning G, Wang W, Wang J, Liu R. Obesity-enriched gut microbe degrades myo-inositol and promotes lipid absorption. Cell Host Microbe. 2024 Aug 14;32(8): 1301-1314.e9. Full text （影响因子20.6，中科院1区/JCR Q1区，肌醇定量）
Feng S, Wang D, Jin Y, Huang S, Liang T, Sun W, Du X, Zhuo L, Shan C, Zhang W, Jing T, Zhao S, Hong R, You L, Liu G, Chen L, Ye D, Li X, Yang Y. Blockage of L2HGDH-mediated S-2HG catabolism orchestrates macrophage polarization to elicit antitumor immunity. Cell Rep. 2024, Jun 25; 43(6): 114300. Full text （影响因子7.5，中科院1区/JCR Q1区，手性2-羟基戊二酸定量）
Wang Y, Shu H, Qu Y, Jin X, Liu J, Peng W, Wang L, Hao M, Xia M, Zhao Z, Dong K, Di Y, Tian M, Hao F, Xia C, Zhang W, Ba X, Feng Y, Wei M. PKM2 functions as a histidine kinase to phosphorylate PGAM1 and increase glycolysis shunts in cancer. EMBO J. 2024, Jun; 43(12): 2368-2396. Full text （影响因子6.9，中科院1区/JCR Q1区，肿瘤-中心碳代谢-代谢流）
Tang Y, Wu J, Sun X, Tan S, Li W, Yin S, Liu L, Chen Y, Liu Y, Tan Q, Jiang Y, Yang W, Huang W, Weng C, Wu Q, Lu Y, Yuan H, Xiao Q, Chen AF, Xu Q, Billiar TR, Cai J. Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia. Cell Rep. 2024, May 28; 43(5): 114237. Full text （影响因子7.5，中科院1区/JCR Q1区，心脏线粒体 氧化心磷脂）
Wang Y, Cheng C, Lu Y, Lian Z, Liu Q, Xu Y, Li Y, Li H, Zhang L, Jiang X, Li B, Yu D. β-Catenin Activation Reprograms Ammonia Metabolism to Promote Senescence Resistance in Hepatocellular Carcinoma. Cancer Res. 2024, May 15; 84(10): 1643-1658. Full text （影响因子12.5，中科院1区/JCR Q1区，肝肿瘤-氨代谢流）
Xie W, Wang J, Tian S, Zhao H, Cao L, Liang Z, Yang J, Zhao Y, Wang B, Jiang F, Ma J. RNF126-mediated ubiquitination of FSP1 affects its subcellular localization and ferroptosis. Oncogene. 2024, May; 43(19): 1463-1475. Full text （影响因子6.9，中科院1区/JCR Q1区，铁死亡-辅酶Q10定量）
Chen KH, Feng J, Bodelier PLE, Yang Z, Huang Q, Delgado-Baquerizo M, Cai P, Tan W, Liu YR. Metabolic coupling between soil aerobic methanotrophs and denitrifiers in rice paddy fields. Nat Commun. 2024, Apr 24; 15(1): 3471. Full text（影响因子14.7，中科院1区/JCR Q1区，土壤微生物-甲烷代谢流-短链脂肪酸）
Guo X, Ji N, Guo Q, Wang M, Du H, Pan J, Xiao L, Gupta N, Feng Y, Xia N. Metabolic plasticity, essentiality and therapeutic potential of ribose-5-phosphate synthesis in Toxoplasma gondii. Nat Commun. 2024, Apr 8; 15(1): 2999. Full text （影响因子14.7，中科院1区/JCR Q1区，寄生虫-中心碳代谢-代谢流）
Lai Y, Gao Y, Lin J, Liu F, Yang L, Zhou J, Xue Y, Li Y, Chang Z, Li J, Chao T, Chen J, Cheng X, Gao X, Li X, Lu F, Chu Q, Wang W. Dietary elaidic acid boosts tumoral antigen presentation and cancer immunity via ACSL5. Cell Metab. 2024, Apr 2; 36(4): 822-838.e8. Full text （影响因子27.7，中科院1区/JCR Q1区，肿瘤免疫-脂肪酸降解代谢流-酰基辅酶A）
Han X, Wang D, Yang L, Wang N, Shen J, Wang J, Zhang L, Chen L, Gao S, Zong WX, Wang Y. Activation of polyamine catabolism promotes glutamine metabolism and creates a targetable vulnerability in lung cancer. Proc Natl Acad Sci U S A. 2024, Mar 26;121(13): e2319429121. Full text （影响因子9.4，中科院1区/JCR Q1区，肺癌多胺代谢-谷氨酰胺代谢流）
Wang Y, Shi Y, Li W, Han X, Lin X, Liu D, Lin Y, Shen L. Knockdown of BRAWNIN minimally affect mitochondrial complex III assembly in human cells. Biochim Biophys Acta Mol Cell Res. 2024 Jan; 1871(1): 119601. Full text （影响因子4.6，中科院2区/JCR Q2区，代谢流）
2023年（内容逐渐恢复中）：
Lu X, Hong J, Zhang J, Liu Q, Liao G, Shi Y, Tang H, Liu X. Triphenyl phosphate disrupts placental tryptophan metabolism by activating MAOA/ROS/NFκB. Sci Total Environ. 2023 Dec 15; 904: 166688. Full text （影响因子9.8，中科院1区/JCR Q1区，环境医学-色氨酸代谢物定量）
Mei J, Liu X, Liu X, Bao Y, Luo T, Wang J. Metabolomics analysis of the metabolic effects of citric acid on Issatchenkia terricola WJL-G4. J Biosci Bioeng. 2023 Dec; 136(6): 452-461. Full text（影响因子2.3，中科院4区/JCR Q3区，酵母菌-LC-MS非靶向代谢组）
He K, Wang Q, Gao X, Tang T, Ding H, Long S. Transcriptomic and metabolomic analyses reveal the essential nature of Rab1B in Toxoplasma gondii. Parasit Vectors. 2023 Nov 8; 16(1): 409. Full text（影响因子3.0，中科院2区/JCR Q1区，弓形虫-GC-MS和LC-MS非靶向代谢组）
Deng Z, Li D, Yan X, Lan J, Han D, Fan K, Chang J, Ma Y. Activation of GABA receptor attenuates intestinal inflammation by modulating enteric glial cells function through inhibiting NF-κB pathway. Life Sci. 2023, Sep 15; 329: 121984. Full text （影响因子6.1，中科院2区/JCR Q1区，神经递质定量）
She H, Tan L, Du Y, Zhou Y, Guo N, Zhang J, Du Y, Wang Y, Wu Z, Ma C, Li Q, Mao Q, Hu Y, Liu L, Li T. VDAC2 malonylation participates in sepsis-induced myocardial dysfunction via mitochondrial-related ferroptosis. Int J Biol Sci. 2023 Jun 14;19(10):3143-3158. Full text （影响因子8.2，中科院2区/JCR Q1区，铁死亡-酰基辅酶A定量）
Tang L, Xu XH, Xu S, Liu Z, He Q, Li W, Sun J, Shuai W, Mao J, Zhao JY, Jin L. Dysregulated Gln-Glu-α-ketoglutarate axis impairs maternal decidualization and increases the risk of recurrent spontaneous miscarriage. Cell Rep Med. 2023, May 16; 4(5): 101026.Full text 影响因子14.3，中科院1区/JCR Q1区，生育-非靶向代谢组-靶向定量-代谢流）
Su X, Cui H, Zhang W. Copiotrophy in a Marine-Biofilm-Derived Roseobacteraceae Bacterium Can Be Supported by Amino Acid Metabolism and Thiosulfate Oxidation. Int J Mol Sci. 2023 May 11;24(10):8617. Full text （影响因子14.3，中科院1区/JCR Q1区，细菌生物膜-游离和结合氨基酸定量）
Zheng X, Zhang W, Hu Y, Zhao Z, Wu J, Zhang X, Hao F, Han J, Xu J, Hao W, Wang R, Tian M, Radak Z, Nakabeppu Y, Boldogh I, Ba X. DNA repair byproduct 8-oxoguanine base promotes myoblast differentiation. Redox Biol. 2023, May;61:102634. Full text （影响因子11.4，中科院1区/JCR Q1区，8-Hydroxyguanine或8-oxoguanine定量）
Wang K, Da Y, Bi HR, Liu YH, Chen BQ, Wang M, Liu ZH, Nielsen J, Tan TW. A one-carbon chemicals conversion strategy to produce precursor of biofuels with Saccharomyces cerevisiae. Renew Ener. 2023, 208: 331-340. Full text （影响因子9，中科院2区/JCR Q1区，生物燃料-13C代谢流）
Song Y, Zheng K, Brede DA, Gomes T, Xie L, Kassaye Y, Salbu B, Tollefsen KE. Multiomics Point of Departure (moPOD) Modeling Supports an Adverse Outcome Pathway Network for Ionizing Radiation. Environ Sci Technol. 2023 Feb 28;57(8):3198-3205. Full text （影响因子11.4，中科院1区/JCR Q1区，环境-斑马鱼多组学-非靶向代谢组）
Lv Y, Tang W, Xu Y, Chang W, Zhang Z, Lin Q, Ji M, Feng Q, He G, Xu J. Apolipoprotein L3 enhances CD8+ T cell antitumor immunity of colorectal cancer by promoting LDHA-mediated ferroptosis. Int J Biol Sci. 2023 Feb 13; 19(4): 1284-1298. Full text （影响因子9.2，中科院2区/JCR Q1区，结肠癌-铁死亡-氧化脂肪酸Oxylipins定量）
Wan W, Dong H, Lai DH, Yang J, He K, Tang X, Liu Q, Hide G, Zhu XQ, Sibley LD, Lun ZR, Long S. The Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments. Nat Commun. 2023 Feb 22;14(1): 977. Full text（影响因子14.7，中科院1区/JCR Q1区，弓形虫-GC-MS和LC-MS非靶向代谢组）
Gan X, Ren J, Huang T, Wu K, Li S, Duan Y, Wang Z, Si W, Wei J. Pathological α-synuclein accumulation, CSF metabolites changes and brain microstructures in cynomolgus monkeys treated with 6-hydroxydopamine. Neurotoxicology. 2023 Jan; 94: 172-181. Full text （影响因子3.4，中科院3区/JCR Q2区，食蟹猴-脑脊液-神经递质定量）
2022年（内容逐渐恢复中）：
Wang R, Jian Q, Hu G, Du R, Xu X, Zhang F. Integrated Metabolomics and Transcriptomics Reveal Metabolic Patterns in Retina of STZ-Induced Diabetic Retinopathy Mouse Model. Metabolites. 2022 Dec 9;12(12):1245. Full text （影响因子4.1，中科院3区/JCR Q2区，糖尿病肾病-视网膜-HILIC非靶向代谢组）
Li Y, Li B, Xu Y, Qian L, Xu T, Meng G, Li H, Wang Y, Zhang L, Jiang X, Liu Q, Xie Y, Cheng C, Sun B, Yu D. GOT2 Silencing Promotes Reprogramming of Glutamine Metabolism and Sensitizes Hepatocellular Carcinoma to Glutaminase Inhibitors. Cancer Res. 2022. Sep 16; 82(18): 3223-3235. Full text （影响因子12.5，中科院1区/JCR Q1区，肝肿瘤-谷氨酰胺代谢流-碳氮双标）
Wang Y, Gao X, Yang H. Integrated metabolomics of "big six" Escherichia coli on pea sprouts to organic acid treatments. Food Res Int. 2022 Jul;157:111354. Full text （影响因子7.425，中科院1区/JCR Q1区，农产品-抑菌-非靶向代谢组）
Yang HH, Jiang HL, Tao JH, Zhang CY, Xiong JB, Yang JT, Liu YB, Zhong WJ, Guan XX, Duan JX, Zhang YF, Liu SK, Jiang JX, Zhou Y, Guan CX. Mitochondrial citrate accumulation drives alveolar epithelial cell necroptosis in lipopolysaccharide-induced acute lung injury. Exp Mol Med. 2022 Nov; 54(11): 2077-2091. Full text （影响因子12.8，中科院2区/JCR Q1区，肺损伤-GC-MS非靶向代谢组）
Li Y, Li B, Xu Y, Qian L, Xu T, Meng G, Li H, Wang Y, Zhang L, Jiang X, Liu Q, Xie Y, Cheng C, Sun B, Yu D. GOT2 Silencing Promotes Reprogramming of Glutamine Metabolism and Sensitizes Hepatocellular Carcinoma to Glutaminase Inhibitors. Cancer Res. 2022 Sep 16; 82(18): 3223-3235. Full text （影响因子11.2，中科院1区/JCR Q1区，肝细胞肿瘤-13C-15N-代谢流）
Feng T, Zhao X, Gu P, Yang W, Wang C, Guo Q, Long Q, Liu Q, Cheng Y, Li J, Cheung CKY, Wu D, Kong X, Xu Y, Ye D, Hua S, Loomes K, Xu A, Hui X. Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2. Nat Commun. 2022 Sep 5;13(1): 5208. Full text （影响因子14.7，中科院1区/JCR Q1区，13C乳酸代谢流）
Wongmaneepratip W, Gao X, Yang H. Effect of food processing on reduction and degradation pathway of pyrethroid pesticides in mackerel fillet (Scomberomorus commerson). Food Chem. 2022 Aug 1; 384: 132523. Full text （影响因子8.8，中科院1区/JCR Q1区，食品加工-农残降解-质谱鉴定）
Yang J, Guan Y, Chen J, Su Y, Zhang S, Mehmood K, Saleem MU, Shi D. Effects of echinacea extract on intestinal metabolomics in immunosuppressive rats. Pak Vet J, 2022 June; 42(3): 390-396. Full text （影响因子2.3，中科院4区/JCR Q1区，粪便GC-MS非靶向代谢组）
Shi Z, Gan G, Gao X, Chen F, Mi J. Kynurenine catabolic enzyme KMO regulates HCC growth. Clin Transl Med. 2022 Feb;12(2): e697. Full text （影响因子10.6，中科院1区/JCR Q1区，肝癌-色氨酸代谢）
2021年（内容逐渐恢复中）：
Zhang XJ, Ji YX, Cheng X, Cheng Y, Yang H, Wang J, Zhao LP, Huang YP, Sun D, Xiang H, Shen LJ, Li PL, Ma JP, Tian RF, Yang J, Yao X, Xu H, Liao R, Xiao L, Zhang P, Zhang X, Zhao GN, Wang X, Hu ML, Tian S, Wan J, Cai J, Ma X, Xu Q, Wang Y, Touyz RM, Liu PP, Loomba R, She ZG, Li H. A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques. Sci Transl Med. 2021 Dec 15; 13(624): eabg8116. Full text （影响因子 17.1，中科院1区/JCR Q1区，非酒精性脂肪肝-乙酸钠-脂肪酸合成代谢流）
Shi Z, Gan G, Xu X, Zhang J, Yuan Y, Bi B, Gao X, Xu P, Zeng W, Li J, Ye Y, Zhou A, Zhang N, Liu W, Lin S, Mi J. Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1. J Hematol Oncol. 2021 Sep 25;14(1):153. Full text （影响因子23.168，中科院1区/JCR Q1区，基础医学-色氨酸代谢）
Tian M, Hao F, Jin X, Sun X, Jiang Y, Wang Y, Li D, Chang T, Zou Y, Peng P, Xia C, Liu J, Li Y, Wang P, Feng Y, Wei M. ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation. Elife. 2021 Sep 7;10: e62394. Full text （影响因子8.713，中科院1区/JCR Q1区，Glucose-13C6-脂肪酸代谢流）
2020年：
GUO Wenzheng, LI Kaimi, LIN Shuhai*, Deng Jiong*, et al. Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc- for Glutathione Synthesis in Lung Cancer. Cancer Res. 2020 . Full text （影响因子 9.727，JCR 一区，细胞-靶向代谢物定量）
HU Xiaoyu, GUO Jian, ZHAO Caijun, JIANG Peng, MAIMAI T, YANYI Li, CAO Yongguo, FU Yunhe*, ZHANG Naisheng*. The gut microbiota contributes to the development of Staphylococcus aureus-induced mastitis in mice. ISME Journal. 2020,14(7):1897-1910. Full text （影响因子9.180，JCR 一区，乳腺炎-肠道菌群-短链脂肪酸定量）
JIA Yaqian, YUAN Ziwen, ZHANG Xiaosong, DONG Jiaqi, LIU Xuenan, PENG Xiaoting, YAO Wanling, JI Peng, WEI Yanming, HUA Yongli*. Total alkaloids of Sophora alopecuroides L. ameliorated murine colitis by regulating bile acid metabolism and gut microbiota. Journal of Ethnopharmacology. 2020, 255: 112775. Full text（影响因子 3.690，JCR 二区，小鼠-胆汁酸绝对定量）
WANG Pan, GAO jianpeng, KE Weixin, WANG Jing, LI Daotong, LIU Ruolin, JIA Yan, WANG Xuehua, CHEN Xin, CHEN Fang, HU Xiaosong*. Resveratrol reduces obesity in high-fat diet-fed mice via modulating the composition and metabolic function of the gut microbiota. Free Radic Biol Med. 2020,156: 83-98. Full text（影响因子 6.170，JCR 一区，高脂饮食小鼠肠道菌群与白藜芦醇-代谢组与定量）
FU Yi, WANG Dongdong, HE Wei*, ZHANG Jianmin*, et al. TSPO deficiency induces mitochondrial dysfunction, leading to hypoxia, angiogenesis, and a growth-promoting metabolic shift toward glycolysis in glioblastoma. Neuro-oncology, 2020, 22(2): 240-252. Full text（影响因子 10.247，JCR 一区，神经胶质母细胞瘤-代谢流）
GAO Jing, WEI Tong, HUANG Chenglin, SUN Mengwei, SHEN Weili*. Sirtuin 3 governs autophagy‐dependent glycolysis during Angiotensin II‐induced endothelial‐to‐mesenchymal transition. FASEB Journal, 2020, 34(12): 16645-16661. Full text （影响因子 4.966，JCR 一区，高血压-细胞-代谢流）
QIU Yixuan (邱轶轩), SHEN Linyan, NING Guang* (中国工程院院士), GU Yanyun*, et al. The glucose-lowering effects of α-glucosidase inhibitor require a bile acid signal in mice. Diabetologia. 2020, 63(5): 1002-1016. Full text （影响因子 7.518，JCR 一区，2型糖尿病-肠道菌群-胆汁酸定量）
SUN Silei (孙思磊), ZHAO Bing, CHEN Erzhen*, MAO Enqiao*. TUDCA ameliorates liver injury via activation of SIRT1-FXR signaling in a rat hemorrhagic shock model. Shock. 2020, 53(2): 217-222. Full text （影响因子 2.960，JCR 二区，鼠失血性休克-肝损伤-胆汁酸定量）
FANG Sijie (方思捷), ZHANG Shuo, HUANG Yazhuo, ZHOU Huifang*, FAN Xianqun*, et al. Evidence for associations between Th1/Th17 "Hybrid" phenotype and altered lipometabolism in very severe graves orbitopathy. Journal of Clinical endocrinology & Metabolism. 2020, 105(6): dgaa124. Full text （影响因子 5.493，JCR 一区，眼病-临床血清-脂质组学）
Dai Weiqi (戴维奇), Xu L, Yu X, Zhang G, Guo H, Liu H, Song G, Weng S, Dong L, Zhu J, Liu T, Guo C, Shen Xizhong. OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism. J Hepatol. 2020 May;72(5): 909-923. doi: 10.1016/j.jhep.2019.12.015. Epub 2019 Dec 30. PMID: 31899205. Full text （影响因子 25.084，中科院1区/JCR 一区，复旦大学附属中山医院-消化内科-肝肿瘤-代谢流）
CHEN Diling, GUO Yinrui, XIE Yizhen*, WU Qingping*, et al. Metabolic regulation of Ganoderma lucidum extracts in high sugar and fat diet-induced obese mice by regulating the gut-brain axis. Journal of Functional Foods. 2020, 65: 103639. Full text （影响因子 3.701，JCR 二区，粪便-代谢组学）
FANG Xuexian (方学贤), CAI Zhaoxian, MIN Junxia*, WANG Fudi*, et al. Loss of cardiac ferritin H facilitates cardiomyopathy via Slc7a11-mediated ferroptosis. Circulation Research. 2020, 127(4): 486-501. Full text （影响因子 14.467，JCR 一区，谷胱甘肽、半胱氨酸等靶向代谢组定量）
WANG Xifan (王希璠), YANG Songtao, Ehrlich Stanislav Dusko*, REN Fazheng*, YU Zhengquan*, et al. Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents. Gut. 2020, 69(12): 2131-2142. Full text （影响因子 19.819，JCR 一区，肾衰竭-尿毒症毒素-肠道微生物肠道菌群-粪便胆汁酸代谢物定量）
Lei C, Chen J, Li H, Fan T, Zheng X, Wang H, Zhang N, Liu Y, Luo X, Wang J, Wang A. Role of the Mitochondrial Citrate-malate Shuttle in Hras12V-Induced Hepatocarcinogenesis: A Metabolomics-Based Analysis. Metabolites. 2020, 10(5): 193. Full text（JCR 二区，肝肿瘤-代谢组与中心碳代谢代谢流）
LIANG Xiaohan, CUI Jianmin, SHEN Bang*, et al. Acquisition of exogenous fatty acids renders apicoplast-based biosynthesis dispensable in tachyzoites of Toxoplasma. Journal of Biological Chemistry. 2020, 295(22): 7743-7752. Full text （影响因子 4.238，弓形虫-脂肪酸代谢流）
Zhao M, Hou Y, Du YE, Yang L, Qin Y, Peng M, Liu S, Wan X, Qiao Y, Zeng H, Cui X, Teng Y, Liu M. Drosha-independent miR-6778-5p strengthens gastric cancer stem cell stemness via regulation of cytosolic one-carbon folate metabolism. Cancer Lett. 2020 May 28; 478: 8-21. Full text （影响因子 7.36，一碳代谢四氢叶酸代谢流）
LIU Fei, ZHANG Hui, DING Ling, XIANG Yong*, et al. REVERSAL OF RDO5 1, a Homolog of rice seed dormancy 4, interacts with bHLH57 and controls ABA biosynthesis and seed dormancy in Arabidopsis. Plant Cell, 2020, 32(6): 1933-1948. Full text （影响因子 8.631，JCR 一区，拟南芥-植物激素定量）
DING Xisheng, SUN Wen, DAI Lili, LIU Chunsheng, SUN Qian, WANG Jianghua, ZHANG Panwei, LI Kun, YU Liqin*.Parental exposure to environmental concentrations of tris(1,3-dichloro-2-propyl)phosphate induces abnormal DNA methylation and behavioral changes in F1 zebrafish larvae. Environmental Pollution, 2020, 267: 115305. Full text （影响因子 6.791，JCR 一区，斑马鱼-神经递质定量）
ZHU Mingzhe, LI Meng, ZHANG Li*, JI Gaung*, et al. Metabolomic analysis identifies glycometabolism pathways as potential targets of Qianggan Extract in hyperglycemia rats. Frontiers in Pharmacology, 2020, 11: 671. Full text （影响因子 4.225，JCR 一区，中药药理-代谢组）
DONG Zhen, LI Ruoshui, XU Lei, XIN Kaiyue, SUN Aijun*, GE Junbo* (中国工程院院士), et al. Histone hyperacetylation mediates enhanced IL-1β production in LPS/IFN-γ-stimulated macrophages. Immunology, 2020, 160(2): 183-197. Full text （影响因子 5.016，JCR 二区，巨噬细胞-代谢流）
CHEN Lingling, XIA Fangsha, MAO Peisheng*, et al. Metabolomic analyses of alfalfa (Medicago sativa L. cv. ‘Aohan’) reproductive organs under boron deficiency and surplus conditions. Ecotoxicology and Environmental Safety, 2020, 202: 111011. Full text （影响因子 4.872，JCR 一区，苜蓿-代谢组学）
2019年：
中国医学科学院北京协和医学院-病毒与细胞-代谢组&代谢物定量
LIU Yang, YOU Yuling, CAO Xuetao* (中国工程院院士), et al. N6-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication.Science, 2019, 365: 1171-1176. Full text （影响因子 41.845，JCR 一区）
复旦大学附属华山医院-肝癌细胞-乙酰辅酶A定量
LU Ming*, ZHU Wen-Wei, QIN Lun-Xiu*, et al. ACOT12-dependent alteration of acetyl-CoA drives hepatocellular carcinoma metastasis by epigenetic induction of epithelial-mesenchymal transition. Cell Metabolism, 2019, 29: 886-900. Full text （影响因子 21.567，JCR 一区）
河南大学基础医学院-纳米材料毒性-动物血清-代谢组学
YANG Yanjie, LV Shuangyu*, JI Shaoping*, et al. Toxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice. International Journal of Nanomedicine, 2019, 14: 6297-6311. Full text （影响因子 5.115，JCR 二区）
中国科学院上海生物化学与细胞生物学研究所-神经-恶性胶质瘤细胞-糖代谢定量
WANG Xiongjun, LIU Ruilong, LI Guohui*, YANG Weiwei*, et al. α-Ketoglutarate-activated NF-κB signaling promotes compensatory glucose uptake and brain tumor development. Molecular Cell, 2019, 76(1): 148-162.e7 Full text （影响因子 15.584，JCR 一区）
中国农业大学食品科学与营养工程学院-肥胖与代谢综合征-中药生姜-糖代谢定量
WANG Jing, LI Daotong, WANG Pan, HU Xiaosong, CHEN Fang. Ginger prevents obesity through regulation of energy metabolism and activation of browning in high-fat diet-induced obese mice. Journal of Nutritional Biochemistry. 2019, 70: 105-115. Full text （影响因子 4.873，JCR 一区）
南开大学-郭建爽-GC-MS代谢组学
Guo Jianshuang, Xue Qingqing, Liu Kaihui, Ge W, Liu W, Wang J, Zhang M, Li QY, Cai D, Shan C, Zhang C, Liu X, Li Jing. Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis. Front Oncol. 2019 Oct 2; 9: 993. Full text
昆明理工大学-灵长类动物(食蟹猴)-血与脑脊液-神经递质定量
ZHANG Bo*, ZHOU Zhigang, JI Weizhi (中国科学院院士), CHEN Yongchang*, et al. Social‐valence‐related increased attention in rett syndrome cynomolgus monkeys: An eye‐tracking study.Autism Research, 2019, 12: 1585–1597. Full text （影响因子 3.727，JCR 三区）
上海交通大学医学院-肥胖相关的胰岛素抵抗-支链氨基酸与支链羰酸定量
ZHOU Meiyi, SHAO Jing, WU Cheng-Yang, SHU Le, SUN Haipeng*, et al. Targeting BCAA catabolism to treat obesity-associated insulin resistance. Diabetes. 2019, 68(9): 1730-1746. Full text （影响因子 7.72，JCR 一区）
上海中医药大学附属龙华医院-中药-动物糖尿病-血清组织粪便-代谢组学
LI Meng, DANG Yanqi, ZHANG Li*, JI Guang*, et al. Berberine alleviates hyperglycemia by targeting hepatic glucokinase in diabetic db/db mice. Scientific Reports. 2019, 9(1): 8003. Full text （影响因子 3.998，JCR 一区）
上海东方肝胆医院-临床-肝癌组织-代谢物定量
LIU Jiao, JIANG Jinhua, WANG Hailin*, HE Yufei*, WANG Hongyang*, et al. Global DNA 5-hydroxymethylcytosine and 5-formylcytosine contents are decreased in the early stage of hepatocellular carcinoma. Hepatology, 2019, 9(1): 196-208. Full text （影响因子 14.679，JCR 一区）
上海中医药大学李后开教授-肠道菌群-血清-GC-MS非靶向代谢组学
GU Yu, LIU Can, ZHANG Weidong*, LI Houkai*, et al. Metabolic and gut microbial characterization of obesity-prone mice under a high-fat diet. Journal of Proteome Research, 2019, 18(4): 1703-1714. Full text （影响因子 4.074，JCR 一区）
中国科学院上海生物化学与细胞生物学研究所-肿瘤细胞-代谢流
LIU Ruilong, LI Wenfeng, YANG Weiwei*, et al. Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance. Nature Communications, 2019, 10: 991. Full text （影响因子 12.121，JCR 一区）
第四军医大学西京医院-李霞-张耀-肿瘤细胞-代谢流
Zhang Y, Lv W, Li Q, Wang Q, Ru Y, Xiong X, Yan F, Pan T, Lin W, Li X. IDH2 compensates for IDH1 mutation to maintain cell survival under hypoxic conditions in IDH1‑mutant tumor cells. Mol Med Rep. 2019 Aug;20(2):1893-1900. Full text （影响因子 3.37，JCR 二区）
华中农业大学-寄生虫机制-代谢流 美国微生物协会期刊
XIA Ningbo, YE Shu, LIANG Xiaohan, SHEN Bang*, et al. Pyruvate homeostasis as a determinant of parasite growth and metabolic plasticity in Toxoplasma gondii. mBio, 2019, 10: e00898-19. Full text （影响因子 6.784，JCR 一区）
中国农业大学-药物毒理学-动物组织-脂质组
YANG Xuan, XU Wentao, HE Xiaoyun*, et al. Precision toxicology shows that troxerutin alleviates ochratoxin A–induced renal lipotoxicity. FASEB Journal, 2019, 33(2): 2212-2227. Full text （影响因子 4.966，JCR 一区）
中国医学科学院病原生物学研究所-病毒(寨卡病毒)-细胞和组织-脂质组学
ZHOU Jia, CHI Xiaojing, YANG Wei*, et al. Zika virus degrades the ω-3 fatty acid transporter Mfsd2a in brain microvascular endothelial cells and impairs lipid homeostasis. Science Advances. 2019, 5(10): eaax7142. Full text （影响因子 13.116，JCR 一区）
2018年：
北京生命科学研究所北京蛋白质组研究中心-肝癌-细胞-代谢组与脂质组学
CAI Mengjiao, SUN Xiao, HAN Suxia*, CHEN Huan*, ZHANG Pumin*, et al. Disruption of peroxisome function leads to metabolic stress, mTOR inhibition, and lethality in liver cancer cells. Cancer Letters, 2018, 421: 82-93. Full text （影响因子 7.360，JCR 一区）
中南大学湘雅医院-肺癌-细胞-代谢流
LI Jiangjiang, HE Ya, CAO Ya*, et al. Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancer. Theranostics, 2018, 8(15): 4050-4061. Full text （影响因子 8.579，JCR 一区）
复旦大学附属上海公共卫生临床中心卢洪洲-艾滋病-血浆-色氨酸代谢物定量
CHEN Jun, XUN Jingna, LU Hongzhou*, et al. Plasma indoleamine 2, 3-dioxygenase activity is associated with the size of the human immunodeficiency virus reservoir in patients receiving antiretroviral therapy. Clinical Infectious Diseases, 2018, 68(8): 1274-1281. Full text （影响因子 8.313，JCR 一区）
上海交通大学医学院附属瑞金医院-2型糖尿病-抗生素-血浆-粪便-肠道菌群-短链脂肪酸-胆汁酸定量
FU Lihong, QIU Yixuan, NING Guang (中国工程院院士), NIE Aifang*, GU Yanyun*, et al. The delayed effects of antibiotics in type 2 diabetes, friend or foe? Journal of Endocrinology, 2018, 238(2): 137-149. Full text（影响因子 4.041，JCR 一区）
暨南大学生物转化医学研究院-高云飞团队-代谢流
XIA Xichun, ZHOU Wei, GUO Chengbin, FU Zhen, ZHU Leqing, LI Peng, XU Yan, ZHENG Liangyan, ZHANG Hua, SHAN Changliang, GAO Yunfei*. Glutaminolysis Mediated by MALT1 Protease Activity Facilitates PD-L1 Expression on ABC-DLBCL Cells and Contributes to Their Immune Evasion. Front Oncol. 2018, 8: 632. Full text （影响因子 4.848，JCR 二区）
中国科学院上海生物化学与细胞生物学研究所-杨巍维团队-巨噬细胞-代谢流
ZHANG Yajuan, YU Guanzhen, LI Guohui*, YANG Weiwei*, et al. Macrophage-associated PGK1 phosphorylation promotes aerobic glycolysis and tumorigenesis. Molecular Cell, 2018, 71(2): 201-215.e7 Full text （影响因子 15.584，JCR 一区）
四川农业大学-植物组织(玉米幼苗)-缺磷-基因组-非靶向代谢组学
LUO Bowen, MA Peng, GAO Shibin*, et al. Metabolite profiling and genome-wide association studies reveal response mechanisms of phosphorus deficiency in maize seedling. Plant Journal, 2018, 97(5): 947–969. Full text （影响因子 6.141，JCR 一区）
西北农林科技大学-动物(鸡)-非酒精性脂肪肝-脂代谢-叶酸-非靶向代谢组
LIU Yanli, SHEN Jing, YANG Xiaojun*, et al. Folic acid reduced triglycerides deposition in primary chicken hepatocytes. Journal of Agricultural and Food Chemistry, 2018, 66: 13162-13172. Full text （影响因子 4.192，JCR 一区）
中国农科院植物保护研究所-贝莱斯芽孢杆菌-非靶向代谢组
WANG Junqiang, GUO Rongjun*, LI Shidong*, et al. Insight in o the surfactin production of Bacillus velezensis B006 through metabolomics analysis. Journal of Industrial Microbiology & Biotechnology, 2018, 45(12):1033-1044. Full text （影响因子 1.681，JCR 二区）
上海交通大学医学院附属仁济医院-结肠癌-细胞-代谢组学&代谢流
WANG Yun-Qian, WANG Hao-Lian, CHEN Ying-Xuan*, et al. Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner. Nature Communications. 2018, 9: 545. Full text （影响因子 12.121，JCR 一区）
中国农业大学-肠道微生物(肠道菌群)-粪便-短链脂肪酸-芳香类物质-非靶向代谢组&靶向定量(芳香类物质定量)
LI Daotong, WANG Pan, CHEN Fang*, et al. Gut microbiota promotes production of aromatic metabolites through degradation of barley leaf fiber. Journal of Nutritional Biochemistry, 2018, 58: 49-58. Full text （影响因子 4.873，JCR 一区）
华中农业大学水产学院-环境污染-神经毒性-斑马鱼-神经递质定量
GUO Xiaochun, ZHANG Shengnan, LU Shaoyong*, ZHENG Binghui, XIE Ping, CHEN Jun, LI Guangyu, LIU Chunsheng, WU Qin, CHENGE Houcheng, SANG Nan. Perfluorododecanoic acid exposure induced developmental neurotoxicity in zebrafish embryos. Environmental Pollution, 2018, 241: 1018-1026. Full text （影响因子 6.791，JCR 一区）
华中农业大学-寄生虫-细胞-代谢流
XIA Ningbo, YANG Jichao, SHEN Bang*, et al. Functional analysis of Toxoplasma lactate dehydrogenases suggests critical roles of lactate fermentation for parasite growth in vivo. Cellular Microbiology, 2018, 20(1): e12794. Full text （影响因子 3.430，JCR 二区）
西北农林科技大学动物科技学院-鸡-肝脏-非靶向代谢组学
WU Shengru, LIU Yanli, YANG Xiaojun*, et al. Hepatic metabolomic profiling changes along with postnatal liver maturation in breeder roosters. Biology Open, 2018, 7(1): bio028944. Full text （影响因子 2.029，JCR 三区）
2017年：
华南农业大学-病毒-细胞-非靶向代谢组学 Front. Microbiol. IF=4.235
GOU Hongchao, ZHAO Mingqiu, CHEN Jinding*, et al. Metabolic profiles in cell lines infected with classical swine fever virus. Frontiers in Microbiology, 2017, 8: 691. Full text
上海海洋大学-鱼组织-靶向代谢物(视黄酸)定量 Nat. Genet. IF= 27.603
SAHO Changwei, BAO Baolong, Xie ZY, POWER Deborah M*, WANG Qingyin*, SCHARTL Manfred*, CHEN Songlin*, et al. The genome and transcriptome of Japanese flounder provide insights in o flatfish asymmetry. Nature Genetics, 2017, 49: 119-124. Full text
上海交通大学医学院附属瑞金医院-临床2型糖尿病-肠道菌群-血浆胆汁酸定量 Nature Communications IF=12.121
GU Yanyun, WANG Xiaokai, Kristiansen Karsten*, NING Guang*, WANG Weiqing*, et al. Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment. Nature Communications, 2017, 8: 1785. Full text
上海交通大学医学院附属瑞金医院-肥胖-肠道菌群-血清-非靶向代谢组-靶向代谢物定量 Nature Medicine IF=36.130
LIU Ruixin, HONG Jie, NING Guang* (中国工程院院士), Kristiansen Karsten*, WANG Weiqing*, et al. Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention. Nature Medicine, 2017, 23: 859-868. Full text
上海交通大学医学院附属瑞金医院-肥胖-细胞-靶向代谢物定量 Endocrine IF=3.235
NING Tinglu, ZOU Yaoyu, WANG Jiqiu*, NING Guang* (中国工程院院士), et al. Genetic interaction of DGAT2 and FAAH in the development of human obesity. Endocrine, 2017, 56(2): 366-378. Full text
上海中医药大学-肠道菌群-血清-非靶向代谢组-靶向定量（胆汁酸）Journal of proteome research IF=4.074
HE Xuyun, ZHENG Ningning, HE Jiaojiao, LIU Can, FENG Jing, JIA Wei*, LI Houkai*. Gut microbiota modulation attenuated the hypolipidemic effect of simvastatin in high-fat/cholesterol-diet fed mice. J Proteome Res. 2017,16(5): 1900-1910. Full text
上海中医药大学-中药毒性研究-尿液-非靶向代谢组学
HU Xueqing, SHEN Jiaying, PU Xueyan, ZHENG Ningning, DENG Zhongping, ZHANG Zean, LI Houkai*. Urinary time- or dose-dependent metabolic biomarkers of aristolochic acid-induced nephrotoxicity in rats. Toxicological Sciences. 2017, 156(1): 123-132. Full text （影响因子 3.703，JCR 一区）
华中农业大学水产学院-微囊藻毒素-神经毒性-斑马鱼-神经递质定量
WU Qin, YAN Wei, CHEN Houcheng, LIU Chunsheng, HUNG Tien-Chieh, GUO Xiaochun, LI Guangyu*. Parental transfer of microcystin-LR induced transgenerational effects of developmental neurotoxicity in zebrafish offspring. Environmental Pollution, 2017, 231: 471-478. Full text （影响因子 6.971，JCR 一区）
中国科学院-食管癌-靶向定量-色氨酸代谢 Biochem Biophys Res Commun. IF=2.985
CHENG Jing, JIN Hai, ZHENG Guangyong*, GAO Xianfu*. Disturbed tryptophan metabolism correlating to progression and metastasis of esophageal squamous cell carcinoma. Biochem Biophys Res Commun. 2017, 486(3): 781-787. Full text
2016年：
江南大学-菌微生物大肠杆-Plos One-GC-MS非靶向 IF 3.234
Liu LN, Duan XG, Wu J. L-Tryptophan Production in Escherichia coli Improved by Weakening the Pta-AckA Pathway. Plos One, 2016.
江南大学-菌微生物大肠杆-Journal of Biotechnology-GC-MS非靶向 IF 3.163
Liu LN, Duan XG, Wu J.Modulating the direction of carbon flow in Escherichia coli to improvel-tryptophan production by inactivating the global regulator FruR. Journal of Biotechnology, 2016.
上海中医药大学-高血脂症药物治疗研究-大鼠血清肝脏粪便-Journal of Tranlational Medicine-GC-MS非靶向 IF 4.098
Li M, Shu XB, Ji G, et al. Integrative analysis of metabolome and gut microbiota in dietinduced hyperlipidemic rats treated with berberine compounds. Journal of Tranlational Medicine, 2016.
扬州大学-肠道菌群-血浆-Scientific Reports GC-MS靶向（短链脂肪酸） IF 4.011
Liu L, Zhao X, Gong DQ, et al. Prosteatotic and Protective Components in a Unique Model of Fatty Liver: Gut Microbiota and Suppressed Complement System. Scientific Reports, 2016.
