中国医学科学院基础医学研究所-神经(胶质母细胞瘤)-代谢流 Neuro-oncology IF=10.247

FU Yi, WANG Dongdong, HE Wei*, ZHANG Jianmin*, et al. TSPO deficiency induces mitochondrial dysfunction, leading to hypoxia, angiogenesis, and a growth-promoting metabolic shift toward glycolysis in glioblastoma. Neuro-oncology, 2020, 22(2): 240-252. Full text

上海交通大学医学院附属瑞金医院-2型糖尿病-肠道菌群-胆汁酸定量 Diabetologia IF=7.518

QIU Yixuan, SHEN Linyan, NING Guang* (中国工程院院士), GU Yanyun*, et al. The glucose-lowering effects of α-glucosidase inhibitor require a bile acid signal in mice. Diabetologia. 2020, 63(5): 1002-1016. Full text

广东省科学院广东省微生物研究所-粪便-代谢组  J Funct. Foods  IF=3.701

CHEN Diling, GUO Yinrui, XIE Yizhen*, WU Qingping*, et al. Metabolic regulation of Ganoderma lucidum extracts in high sugar and fat diet-induced obese mice by regulating the gut-brain axis. Journal of Functional Foods2020, 65: 103639. Full text

浙江大学医学院-心肌细胞铁死亡-靶向代谢物定量(谷胱甘肽、半胱氨酸等)  Circ. Res.  IF=14.467

FANG Xuexian, CAI Zhaoxian, MIN Junxia*, WANG Fudi*, et alLoss of cardiac ferritin H facilitates cardiomyopathy via Slc7a11-mediated ferroptosis. Circulation Research2020, 127(4): 486-501. Full text

中国农业大学-肾衰竭-尿毒症毒素-肠道微生物(肠道菌群)-粪便代谢物定量(胆汁酸)  Gut  IF=19.819

WANG Xifan, YANG Songtao, Ehrlich Stanislav Dusko*, REN Fazheng*, YU Zhengquan*, et al. Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents. GutEpub ahead of print, 2020, Apr 2Full text

华中农业大学动物医学院-寄生虫(弓形虫)-脂肪酸代谢流  J Biol. Chem.  IF=4.238

LIANG Xiaohan, CUI Jianmin, SHEN Bang*, et al. Acquisition of exogenous fatty acids renders apicoplast-based biosynthesis dispensable in tachyzoites of Toxoplasma. Journal of Biological Chemistry. 2020, 295(22): 7743-7752. Full text

中国农业科学院深圳农业基因组研究所-植物(拟南芥)-植物激素定量 Plant Cell IF=8.631 

LIU Fei, ZHANG Hui, DING Ling, XIANG Yong*, et al. REVERSAL OF RDO5 1, a Homolog of rice seed dormancy 4, interacts with bHLH57 and controls ABA biosynthesis and seed dormancy in Arabidopsis. Plant Cell, 2020, 32(6): 1933-1948.  Full text

上海中医药大学附属龙华医院-中药药理-代谢组 Front. Pharmacol. IF=4.225

ZHU Mingzhe, LI Meng, ZHANG Li*, JI Gaung*, et al. Metabolomic analysis identifies glycometabolism pathways as potential targets of Qianggan Extract in hyperglycemia rats. Frontiers in Pharmacology, 2020, 11: 671.  Full text

复旦大学附属中山医院-免疫(巨噬细胞)-代谢流 Immunology  IF=5.016

DONG Zhen, LI Ruoshui, XU Lei, XIN Kaiyue, SUN Aijun*, GE Junbo* (中国工程院院士), et al. Histone hyperacetylation mediates enhanced IL-1β production in LPS/IFN-γ-stimulated macrophages. Immunology, 2020, 160(2): 183-197. Full text

中国农业大学草业科学与技术学院-植物(苜蓿)-代谢组 Ecotoxicol. Environ. Saf. IF=4.872 

CHEN Lingling, XIA Fangsha, MAO Peisheng*, et alMetabolomic analyses of alfalfa (Medicago sativa L. cv. ‘Aohan’) reproductive organs under boron deficiency and surplus conditions. Ecotoxicology and Environmental Safety, 2020, 202: 111011. Full text


中国医学科学院北京协和医学院-病毒与细胞-代谢组&代谢物定量 Science IF=41.845

LIU Yang, YOU Yuling, CAO Xuetao* (中国工程院院士), et al. N6-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication. Science. 2019, 365:1171-1176. Full text

复旦大学附属华山医院-肝癌细胞-乙酰辅酶A定量-Cell Metabolism  IF=22.415

LU Ming*, ZHU Wen-Wei, QIN Lun-Xiu*, et al. ACOT12-dependent alteration of acetyl-CoA drives hepatocellular carcinoma metastasis by epigenetic induction of epithelial-mesenchymal transition. Cell Metabolism, 2019, 29: 886-900. Full text

河南大学基础医学院-纳米材料毒性-动物血清-代谢组 International Journal of Nanomedicine IF=5.115

YANG Yanjie, LV Shuangyu*, JI Shaoping*, et al. Toxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice. International Journal of Nanomedicine, 2019, 14: 6297-6311. Full text

中国科学院上海生物化学与细胞生物学研究所-神经-恶性胶质瘤细胞-糖代谢定量 Molecular cell  IF=15.584

WANG Xiongjun, LIU Ruilong, LI Guohui*, YANG Weiwei*, et alα-Ketoglutarate-activated NF-κB signaling promotes compensatory glucose uptake and brain tumor developmentMolecular Cell, 2019, 76(1): 148-162.e7  Full text

昆明理工大学-灵长类动物(食蟹猴)-血与脑脊液-神经递质定量 Autism Research  IF=3.727

ZHANG Bo*, ZHOU Zhigang, JI Weizhi (中国科学院院士), CHEN Yongchang*, et al. Social‐valence‐related increased attention in rett syndrome cynomolgus monkeys: An eye‐tracking study. Autism Research, 2019, 12: 1585–1597. Full text


上海中医药大学附属龙华医院-中药-动物糖尿病-血清组织粪便-代谢组 Scientific reports IF=3.998

LI Meng, DANG Yanqi, ZHANG Li*, JI Guang*, et al. Berberine alleviates hyperglycemia by targeting hepatic glucokinase in diabetic db/db mice. Scientific Reports. 2019, 9(1): 8003. Full text


上海东方肝胆医院-临床-肝癌组织-代谢物定量 Hepatology  IF=14.971

LIU Jiao, JIANG Jinhua, WANG Hailin*, HE Yufei*, WANG Hongyang*, et al. Global DNA 5-hydroxymethylcytosine and 5-formylcytosine contents are decreased in the early stage of hepatocellular carcinoma. Hepatology, 2019, 9(1): 196-208. Full text


上海中医药大学-肠道菌群-血清-代谢组 Journal of proteome research-GC-MS非靶向 IF=4.074

GU Yu, LIU Can, ZHANG Weidong*, LI Houkai*, et al. Metabolic and gut microbial characterization of obesity-prone mice under a high-fat diet. Journal of Proteome Research, 2019, 18(4): 1703-1714. Full text


中国科学院上海生物化学与细胞生物学研究所-肿瘤细胞-代谢流 Nature communications  IF=12.121

LIU Ruilong, LI Wenfeng, YANG Weiwei*, et al. Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance. Nature Communications, 2019, 10: 991.  Full text


中国农业大学-药物毒理学-动物组织-脂质组 FASEB Journal  IF=4.966

YANG Xuan, XU Wentao, HE Xiaoyun*, et al. Precision toxicology shows that troxerutin alleviates ochratoxin A–induced renal lipotoxicity. FASEB Journal, 2019, 33(2): 2212-2227.  Full text


中国医学科学院病原生物学研究所-病毒(寨卡病毒)-细胞和组织-脂质组 Sci. Adv.  IF=13.116

ZHOU Jia, CHI Xiaojing, YANG Wei*, et al. Zika virus degrades the ω-3 fatty acid transporter Mfsd2a in brain microvascular endothelial cells and impairs lipid homeostasis. Science Advances. 2019, 5(10): eaax7142.  Full text



北京生命科学研究所北京蛋白质组研究中心-肝癌-细胞-代谢组与脂质组 Cancer Lett. IF=7.360

CAI Mengjiao, SUN Xiao, HAN Suxia*, CHEN Huan*, ZHANG Pumin*, et al. Disruption of peroxisome function leads to metabolic stress, mTOR inhibition, and lethality in liver cancer cells. Cancer Letters, 2018, 421: 82-93.  Full text


复旦大学附属上海公共卫生临床中心-艾滋病-血浆-色氨酸代谢物定量 Clin. Infect. Dis. IF=8.313

CHEN Jun, XUN Jingna, LU Hongzhou*, et al. Plasma indoleamine 2, 3-dioxygenase activity is associated with the size of the human immunodeficiency virus reservoir in patients receiving antiretroviral therapy. Clinical Infectious Diseases, 2018, 68(8): 1274-1281. Full text


上海交通大学医学院附属瑞金医院-2型糖尿病-抗生素-血浆-粪便-肠道菌群-短链脂肪酸-胆汁酸 J Endocrinol. IF=4.041

FU Lihong, QIU Yixuan, NING Guang (中国工程院院士), NIE Aifang*, GU Yanyun*, et al. The delayed effects of antibiotics in type 2 diabetes, friend or foe? Journal of Endocrinology, 2018, 238(2): 137-149. Full text


中国科学院上海生物化学与细胞生物学研究所-巨噬细胞-代谢流 Molecular Cell  IF=15.584

ZHANG Yajuan, YU Guanzhen, LI Guohui*, YANG Weiwei*, et al. Macrophage-associated PGK1 phosphorylation promotes aerobic glycolysis and tumorigenesis. Molecular Cell, 2018, 71(2): 201-215.e7  Full text


四川农业大学-植物组织(玉米幼苗)-缺磷-基因组-非靶向代谢组 Plant Journal IF=6.141

LUO Bowen, MA Peng, GAO Shibin*, et al. Metabolite profiling and genome-wide association studies reveal response mechanisms of phosphorus deficiency in maize seedling. Plant Journal, 2018, 97(5): 947–969.   Full text

西北农林科技大学-动物(鸡)-非酒精性脂肪肝-脂代谢-叶酸-非靶向代谢组 J. Agric. Food Chem. IF=4.192

LIU Yanli, SHEN Jing, YANG Xiaojun*, et al. Folic acid reduced triglycerides deposition in primary chicken hepatocytes. Journal of Agricultural and Food Chemistry, 2018, 66: 13162-13172.   Full text


中国农科院植物保护研究所-贝莱斯芽孢杆菌-非靶向代谢组 J Ind Microbiol Biotechnol.  IF=2.824

WANG Junqiang, GUO Rongjun*, LI Shidong*, et al. Insight into the surfactin production of Bacillus velezensis B006 through metabolomics analysis. Journal of Industrial Microbiology & Biotechnology, 2018, 45(12):1033-1044.  Full text

上海交通大学医学院附属仁济医院-结肠癌-细胞-代谢组学&代谢流 Nat Commun IF=12.121

WANG Yun-Qian, WANG Hao-Lian, CHEN Ying-Xuan*, et al. Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner. Nature Communications. 2018, 9: 545.  Full text


中国农业大学-肠道微生物(肠道菌群)-粪便-短链脂肪酸-芳香类物质-非靶向代谢组&靶向定量(芳香类物质定量) Journal of Nutritional Biochemistry IF=4.873

LI Daotong, WANG Pan, CHEN Fang*, et al. Gut microbiota promotes production of aromatic metabolites through degradation of barley leaf fiber. Journal of Nutritional Biochemistry, 2018, 58: 49-58.  Full text

华中农业大学-寄生虫-细胞-代谢流 Cellular Microbiology  IF=3.430

XIA Ningbo, YANG Jichao, SHEN Bang*, et al. Functional analysis of Toxoplasma lactate dehydrogenases suggests critical roles of lactate fermentation for parasite growth in vivoCellular Microbiology, 2018, 20(1): e12794. Full text



华南农业大学-病毒-细胞-非靶向代谢组学 Front. Microbiol. IF=4.235

GOU Hongchao, ZHAO Mingqiu, CHEN Jinding*, et al. Metabolic profiles in cell lines infected with classical swine fever virus. Frontiers in Microbiology, 2017, 8: 691.  Full text

上海海洋大学-鱼组织-靶向代谢物(视黄酸)定量 Nat. Genet. IF= 27.603

SAHO Changwei, BAO Baolong, Xie ZY, POWER Deborah M*, WANG Qingyin*, SCHARTL Manfred*, CHEN Songlin*, et al. The genome and transcriptome of Japanese flounder provide insights into flatfish asymmetry. Nature Genetics, 2017, 49: 119-124.  Full text


上海交通大学医学院附属瑞金医院-临床2型糖尿病-肠道菌群-血浆胆汁酸定量 Nature Communications IF=12.121

GU Yanyun, WANG Xiaokai, Kristiansen Karsten*, NING Guang*, WANG Weiqing*, et al. Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment. Nature Communications, 2017, 8: 1785.  Full text


上海交通大学医学院附属瑞金医院-肥胖-肠道菌群-血清-非靶向代谢组-靶向代谢物定量 Nature Medicine IF=36.130

LIU Ruixin, HONG Jie, NING Guang* (中国工程院院士), Kristiansen Karsten*, WANG Weiqing*, et al. Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention. Nature Medicine, 2017, 23: 859-868.  Full text

上海交通大学医学院附属瑞金医院-肥胖-细胞-靶向代谢物定量 Endocrine IF=3.235

NING Tinglu, ZOU Yaoyu, WANG Jiqiu*, NING Guang* (中国工程院院士), et al. Genetic interaction of DGAT2 and FAAH in the development of human obesity. Endocrine, 2017, 56(2): 366-378.   Full text


上海中医药大学-肠道菌群-血清-Journal of proteome research-GC-MS非靶向 LC-MS靶向定量(胆汁酸)  IF 4.245

He XY, Zheng NN, Li HK, et al. Gut microbiota modulation attenuated the hypolipidemic effect of simvastatin in high-fat/cholesterol-diet fed mice. Journal of Proteome Research, 2017.


上海中医药大学-中药毒性研究-尿液-Toxicological Sciences-GC-MS非靶向IF 3.564

Hu XQ, Shen JJ, Li HK, et al. Urinary Time- or Dose-Dependent Metabolic Biomarkers of Aristolochic Acid-Induced Nephrotoxicity in Rats. Toxicological Sciences, 2017.


中科院-鳞状细胞癌研究-血清-Biochemical and Biophysical Research Communications  LC-MS靶向定量(色氨酸代谢途径)IF 2.705

Cheng J, Jin H, Zheng GY, et al. Disturbed tryptophan metabolism correlating to progression and metastasis of esophageal squamous cell carcinoma. Biochemical and Biophysical Research Communications, 2017.



江南大学-菌微生物大肠杆-Plos One-GC-MS非靶向 IF 3.234

Liu LN, Duan XG, Wu J. L-Tryptophan Production in Escherichia coli Improved by Weakening the Pta-AckA Pathway. Plos One, 2016.


江南大学-菌微生物大肠杆-Journal of Biotechnology-GC-MS非靶向 IF 3.163

Liu LN, Duan XG, Wu J.Modulating the direction of carbon flow in Escherichia coli to improvel-tryptophan production by inactivating the global regulator FruR. Journal of Biotechnology, 2016.


上海中医药大学-高血脂症药物治疗研究-大鼠血清肝脏粪便-Journal of Tranlational Medicine-GC-MS非靶向 IF 4.098

Li M, Shu XB, Ji G, et al. Integrative analysis of metabolome and gut microbiota in dietinduced hyperlipidemic rats treated with berberine compounds. Journal of Tranlational Medicine, 2016.


扬州大学-肠道菌群-血浆-Scientific Reports GC-MS靶向(短链脂肪酸) IF 4.011

Liu L, Zhao X, Gong DQ, et al. Prosteatotic and Protective Components in a Unique Model of Fatty Liver: Gut Microbiota and Suppressed Complement System. Scientific Reports, 2016.



长海医院-食管癌-血清-Journal of proteome research-GC-MS非靶向 IF 4.245

Jin H, Qiao F, Chen L, Gao XF, et al.Serum Metabolomic Signatures of Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma. J Proteome Res, 2014.